Clinical outcomes after sentinel lymph node biopsy in clinically node-negative breast cancer patients

• 발행기관: 대한방사선종양학회
• 저자명: Hee Ji Han MD Ju Ree Kim MD PhD Hee Rim Nam MD PhD Ki Chang Keum MD PhD Chang Ok Suh MD PhD Yong Bae Kim MD PhD
• 간행물 정보: 『대한방사선종양학회지』제32권 제3호, 132~137쪽, 전체 6쪽
• 주제분류: 의약학 > 종양학
• 파일형태: PDF
• 발행일자: 2014.09.30

영문 초록

Purpose: To evaluate non-sentinel lymph node (LN) status after sentinel lymph node biopsy (SNB) in patients with breast cancer and to identify the predictive factors for disease failure. Materials and Methods: From January 2006 to December 2007, axillary lymph node (ALN) dissection after SNB was performed for patients with primary invasive breast cancer who had no clinical evidence of LN metastasis. A total of 320 patients were treated with breast-conserving surgery and radiotherapy. Results: The median age of patients was 48 years, and the median follow-up time was 72.8 months. Close resection margin (RM) was observed in 13 patients. The median number of dissected SNB was two, and that of total retrieved ALNs was 11. Sentinel node accuracy was 94.7%, and the overall false negative rate (FNR) was 5.3%. Eleven patients experienced treatment failure. Local recurrence, regional LN recurrence, and distant metastasis were identified in 0.9%, 1.9%, and 2.8% of these patients, respectively. Sentinel LN status were not associated with locoregional recurrence (p > 0.05). Close RM was the only significant factor for disease-free survival (DFS) in univariate and multivariate analysis. The 5-year overall survival, DFS, and locoregional DFS were 100%, 96.8%, and 98.1%, respectively. Conclusion: In this study, SNB was performed with high accuracy and low FNR and high locoregional control was achieved.

목차

1. Introduction

2. Materials and Methods

3. Results

4. Discussion and Conclusion

5. Conflict of Interest

6. References

키워드

Breast neoplasms Sentinel lymph node biopsy Axillary lymph node dissection Neoplasm recurrence Local