두경부 골수외 형질세포종의 임상적 고찰

• 영문명: Extramedullary Plasmacytoma of the Head and Neck
• 발행기관: 대한두경부종양학회
• 저자명: 심광용(Kwang Yong Shim) 안중배(Joong Bae Ahn) 김귀언(Gwi Eon Kim) 정현철(Hyun Cheol Chung) 김주항(Joo Hang Kim) 김병수(Byung Soo Kim) 노재경(Jae Kyung Roh)
• 간행물 정보: 『대한두경부종양학회지』제15권 제1호, 29~34쪽, 전체 6쪽
• 주제분류: 의약학 > 종양학
• 파일형태: PDF
• 발행일자: 1999.05.30

영문 초록

Objectives: This study was carried out to analyze the clinical profile and the results of treatment of a series of patients with extramedullary plasmacytoma(EMP) of the head and neck. Materials and Methods: The clinical features, treatment and survival of 14 patients with EMP seen at Yonsei Medical Center between 1970 and 1998 were carefully reviewed. Results: The median age was 48 years(range 15-75) and there was a male predominance(M:F 1.8:1). Nasal cavities and paranasal sinuses account for 50% of the primary sites and the most common symptom was airway obstruction(50%). Five patients(36%) showed evidence of adjacent bone destruction, one patient had lymph node involvement and one patient had an IgG monoclonal gammopathy at the time of diagnosis. All 5 patients treated with radiotherapy alone achieved local control. Of 5 patients treated with surgery alone, 2 patients(40%) had local failure. Of 3 patient treated with a combination of surgery and radiotherapy, one patient had local recurrence. A total of7 patients(54%) had local, distant or nodal relapses after primary treatment. Six of them received salvage treatment. With salvage treatment of surgery and/or radiotherapy, local control was achieved in 4 of 6 patients. Conversion to multiple myeloma was seen in one patient. Conclusion: Radiotherapy should be recommanded as treatment of choice for EMP of the head and neck. Surgery should be reserved for radioresistant or recurrent tumors, but tumors that are localized and can be removed relatively easily with little morbidity may be treated by primary surgery.

목차

Abstract

서론

대상 및 방법

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고찰

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References

키워드

Extramedullary plasmacytoma Head and neck