이종이식된 인체 편평상피세포암에 대한 종양괴사인자의 방사선감작효과에 대한 연구

• 영문명: The Radiation Sensitizer Effect of TNF-α on Heterotransplanted Human Squamous Cell Carcinoma
• 발행기관: 대한두경부종양학회
• 저자명: 정필상(Phil Sang Chung) 김한균(Han Gyun Kim) 윤형근(Hyong Geun Yun)
• 간행물 정보: 『대한두경부종양학회지』제14권 제2호, 151~155쪽, 전체 5쪽
• 주제분류: 의약학 > 종양학
• 파일형태: PDF
• 발행일자: 1998.11.30

영문 초록

Background and Objectives: Numerous studies were conducted to develop radiosensitizers to increase antitumor effect and decrease systemic toxicity of ionizing radiation. In current study, the authors tested the synergistic effect of mutant TNF−α(M3S) with radiation therapy on heterotransplanted hypoparyngeal squamous cell carcinoma. Materials and Method: SNU-1041 cell line was heterotransplanted to nude mice. When the tumors grew up to 70mm(3) or more, the animals were randomly placed into 4 groups(n=10/group). Group I : 0.1ml of normal saline injected intraperitoneally once a day for 5 days. Group II : 10ug of TNF-α injected intraperitoneally once a day for 5 days. Group III : a single radiation dose of 10 Gy per animal delivered. Group IV : single radiation dose of 10 Gy was delivered 1 hour after intraperitoneal injection of TNF-α 10 ug. Results: Four weeks after treatment, group IV showed the least tumor growth during the 4 weeks follow up and the relative tumor growth rate(RTG) of each groups after 4 weeks were 31, 5.8, 10, and 3.2 respectively(p<0.05). Conclusion: These study suggests that pretreatment with TNF-α can significantly enhance the effects of radiation therapy and further studies may be needed for clinical trials of combination treatment of TNF-α and radiation.

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TNF-α Radiosensitizer Squamous cell carcinoma