한국인 두경부암 환자에서 제3번 염색체 단완의 결손

• 영문명: Chromosome 3p Deletions in Korean Head and Neck Carcinomas
• 발행기관: 대한두경부종양학회
• 저자명: 손미나(Mi Na Son) 유영아(Young A Yoo) 조증근(Zeung Kenn Cho) 최건(Kun Choi) 최종욱(Jong Wook Choi) 김열홍(Yeul Hong Kim) 김준석(Jun Suk Kim)
• 간행물 정보: 『대한두경부종양학회지』제14권 제1호, 20~26쪽, 전체 7쪽
• 주제분류: 의약학 > 종양학
• 파일형태: PDF
• 발행일자: 1998.05.30

영문 초록

Objectives: Deletion in the short arm of chromosome 3 is common in many human cancers, including sporadic and hereditary renal carcinomas, small cell lung carcinomas, non-small cell lung carcinomas, and carcinomas of the ovary, breast, and cervix. A high frequency of chromosomal aberrations in head and neck cancers involving chromosome 3p has also been reported. These findings suggest that multiple tumor suppressor genes may be present on the short arm of chromosome 3. Materials and Methods: To investigate the possibility of chromosome 3p deletions in the Korean head and neck cancer patients, we applied a polymerase chain reaction(PCR)-based Restriction Fragment Length Polymorphism analysis to the DNA samples of matched normal mucosa and head and neck squamous cell carcinomas from 19 patients. Results: In the 19 normal samples heterozygosity at the polymorphic loci varied: 6 at the D3F15S2 locus(on telomeric 3p21), 2 at the D3S32 locus(on centromeric 3p21), and 4 at the THRB locus(on centromeric 3p24). In 12 matched carcinoma specimens, LOH(loss of heterozygosity) was observed at D3F15S2 in 1 of 6(17%), D3S32 in 1 of 2(50%), and at THRB in 2 of 4 cases(50%). Conclusion: The frequency of chromosome 3p deletion in the Korean head and neck carcinomas appear as other country did.

목차

Abstract

서론

재료 및 연구방법

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고찰

결론

References

키워드

Head and neck cancer PCR-RFLP Loss of heterozygosity