학술논문
Persistent Organic Pollutants and Obesity-Related Metabolic Dysfunction: Focusing on Type 2 Diabetes
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- 영문명
- 발행기관
- 한국역학회
- 저자명
- Duk Hee Lee
- 간행물 정보
- 『Epidemiology and Health』34, 1~3쪽, 전체 2쪽
- 주제분류
- 의약학 > 면역학
- 파일형태
- 발행일자
- 2012.01.25
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국문 초록
영문 초록
Even though obesity is a well-established risk factor of type 2 diabetes, there is emerging evidence that persis-tent organic pollutants (POPs), a variety of lipophilic chemicals accumulated in adipose tissue, may be critically involved in the pathogenesis of type 2 diabetes. Among various POPs, serum concentrations of organochlorine pesticides and polychlorinated biphenyls (PCBs) were the most strongly and consistently linked to type 2 dia-betes in both cross-sectional and prospective studies. In particular, obesity did not seem to be related to type 2 diabetes among persons with very low serum concentrations of POPs, suggesting a more fundamental role of chlorinated POPs in the pathogenesis of type 2 diabetes. These POPs were also associated with obesity, insulin resistance, and adverse lipid profiles like high triglyceride and low high-density lipoprotein (HDL) cholesterol among persons without diabetes, all metabolic dysfunctions commonly observed before developing type 2 dia-betes. Recent animal studies supported the findings from epidemiological studies. If all these findings on POPs are true, it suggests that any effort to reduce the external and internal exposure to POPs would be necessary to decrease the social burden of type 2 diabetes.
목차
Abstract
REFERENCES
키워드
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- Estimation of the Frequency of Intravenous Drug Users in Hamadan City, Iran, Using the Capture-recapture Method
- Persistent Organic Pollutants and Obesity-Related Metabolic Dysfunction: Focusing on Type 2 Diabetes
- Association Between Earlobe Crease and the Metabolic Syndrome in a Cross-sectional Study
- A Population Health Surveillance Theory
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- The Burden of Premature Mortality in Hamadan Province in 2006 and 2010 Using Standard Expected Years of Potential Life Lost: A Population-based Study
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