당뇨황반부종에 대한 트리암시놀론의 유리체강내 주입술과 테논낭하 주입술의 비교

• 영문명: Intravitreal Versus Subtenon Injections of Triamcinolone Acetonide for Diabetic Macular Edema
• 발행기관: 대한안과학회
• 저자명: 권순재 신재필 김시열,Soon Jae Kwon, M.D., Jae Pil Shin, M.D., Si Yeol Kim, M.D.
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume49,number1, 81~90쪽, 전체 10쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2008.01.31

영문 초록

`Purpose: To retrospectively evaluate the clinical effect of intravitreal (IVT) and posterior subtenon (PSTT) triamcinolone acetonide (TA) injection in diabetic macular edema. Methods: Fifty eyes of 43 patients with diabetic macular edema (DME) were included. Twenty-two eyes in the IVT group received 4 mg/0.1 ml intravitreal TA injections and 26 eyes in the PSTT group received 40 mg/1.0 ml subtenon TA injections. LogMAR visual acuity and intraocular pressure (IOP) were measured and, using OCT, central macular thickness (CMT) and total macular volume (TMV) were also measured before and 1, 3, and 6 months postoperatively. Results: Both groups showed significant decreases in the mean CMT and TMV. The mean CMT in the IVT group was significantly thinner than that of the PSTT group 1 month postoperatively. The percentage reduction in CMT and TMV were also greater in the IVT group than the PSTT group 1 month postoperatively. Both groups showed significant improvements in mean visual acuity, with no significant difference between the two groups. However, at 1-month postoperative improvement in visual acuity was significantly greater in the IVT group than the PSTT group. The mean IOP in the IVT group was also greater than that in the PSTT 1 month postoperatively. Conclusions: Both injections caused a significant increase in visual acuity and a decrease in CMT and TMV. The effect was more pronounced in the IVT group. However, the PSTT injection also appeared to be a safe and effective technique for the treatment of DME.`

키워드

Diabetic macular edema, Intravitreal injection, Posterior subtenon injection, Triamcinolone acetonide