순수 유두 갑상선암과 소포 변이 유두 갑상선암: 임상병리학적 특성 비교 연구

• 영문명: The Pure and Follicular Variants of Papillary Thyroid Carcinoma: A Comparative Study of the Clinicopathologic Features
• 발행기관: 대한내분비외과학회
• 저자명: 이병길 윤현조 정성후 Byoung Kil Lee M.D. Hyun Jo Youn M.D. and Sung Hoo Jung M.D.
• 간행물 정보: 『The Koreran journal of Endocrine Surgery』9권1호, 19~23쪽, 전체 5쪽
• 주제분류: 의약학 > 일반외과학
• 파일형태: PDF
• 발행일자: 2009.03.30

영문 초록

Purpose: Pure papillary thyroid carcinoma (PPTC) and the follicular variant of papillary thyroid carcinoma (FVPTC) are the most common subtypes of papillary thyroid carcinoma (PTC). The aim of this study was to investigate if there are any differences in clinicopathological features of these two subgroups. Methods: We performed a retrospective chart review of patients who were treated for PPTC and FVPTC between September 2003 and April 2008. Four hundred fifty patients were shown to have PPTC (91.8%) and forty (8.2%) had FVPTC after a histologic review. The two groups were compared in terms of the clinicopathologic features and the results of preoperative ultrasonography (USG), the fine needle aspiration cytology (FNAC), the frozen section biopsy and the surgical treatment. Results: The tumor size was significantly larger in the FVPTC group than in the PPTC group (1.47 cm versus 1.08 cm, respectively P=0.024). However, both groups had similar clinicopathologic features in terms of age, gender, capsular invasion, multifocality, lymph node metastasis, the MACIS score and the TNM stage. Further, the operative method did not differ between the two groups. The sensitivities of USG and frozen section biopsy for diagnosing FVPTC were significantly lower than those for PPTC (53.85% versus 72.95%, respectively, P=0.045, 81.58% versus 97.25%, respectively, P=0.049). Conclusion: The FVPTC group presented with a larger tumor size, and the clinicopathologic features of the FVPTC group did not significantly differ from those of the PPTC group. Although further studies with longer follow-up are required, these results suggest that the patients in both groups should be treated identically. (Korean J Endocrine Surg 2009;9:19-23)

키워드

유두 갑상선암, 소포 변이, 임상 병리학적 특징,Papillary thyroid carcinoma, Follicular variant, Clinicopathologic feature