갑상선 유두암에서의 bcl-2와 P53 단백질 발현의 의의

• 영문명: The Significance of bcl-2 and P53 Expressions in the Papillary Thyroid Cancer
• 발행기관: 대한내분비외과학회
• 저자명: 지웅배 배정원 우상욱 손길수 이재복 구범환 채양석¹ Woong Bae Ji M.D. Jeoung Won Bae M.D. Sang Uk Woo M.D. Gil Soo Son M.D. Jae Bok Lee M.D. Bum Whan Koo M.D. and Yang-Seok Chae M.D.¹
• 간행물 정보: 『The Koreran journal of Endocrine Surgery』7권4호, 231~236쪽, 전체 6쪽
• 주제분류: 의약학 > 일반외과학
• 파일형태: PDF
• 발행일자: 2007.12.30

영문 초록

Purpose: Papillary thyroid cancer (PTC) has a good prognosis, and it's known to be related to the apoptosis of papillary thyroid cancer. The expression of bcl-2 is thought to be associated with the inhibition of apoptosis. We evaluated the differences of bcl-2 and P53 between PTC and the control (normal tissue and benign lesion). We then analyzed the correlation between the bcl-2 and P53 expressions and the classic prognostic factors. Methods: Between January 2001 and December 2005, 30 patients who underwent total thyroidectomy for the PTC were included in this study and immunohistochemical staining was performed on the tumors. Results: bcl-2 was expressed in 18 cases (60%) in their PTC (P＜0.05). The expression of P53 was not significantly related with the clinicopathological factors, but P53 was expressed in 9 cases (30%) of PTC (P＜0.05). The positive staining for was noted in 18 cases (62.1%) of the PTC tissue among the 30 patients, and as the TNM stage progresses, the expression rate of was significantly decrease for 7 stage I cases (100%), for 4 stage ll cases (80%) and for 7 stage ll cases (38.9%). Conclusion: bcl-2 was expressed more as the TNM stage of PTC decreases. So bcl-2 is possibly useful as a prognostic factor for PTC, but further studies are needed for confirming its significance. (Korean J Endocrine Surg 2007; 7:231-236)

키워드

갑상선 유두암, 예후인자, bcl-2, P53,Papillary thyroid cancer, Prognostic factor, bcl-2, P53