학술논문
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- 영문명
- Multimodal Therapeutic Approach in Anaplastic Thyroid Cancer
- 발행기관
- 대한내분비외과학회
- 저자명
- 서종덕 황규하 정진향 박호용 이영하 Jong Duk Suh M.D. Gyu Ha Hwang M.D. Jin Hyang Jung M.D. Ho Yong Park M.D. and Young Ha Lee M.D.
- 간행물 정보
- 『The Koreran journal of Endocrine Surgery』5권2호, 75~80쪽, 전체 6쪽
- 주제분류
- 의약학 > 일반외과학
- 파일형태
- 발행일자
- 2005.12.30
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국문 초록
영문 초록
Purpose: Anaplastic thyroid cancer (ATC) is a rare but highly aggressive neoplasm with a dismal prognosis. However, a few patients survive for a long time after treatment. We tried to identify prognostic factors of this disease and analyzed treatment outcomes in patients with ATC. Methods: We reviewed the medical records of 15 patients diagnosed with ATC in our institution between 1988 and 2003. The survival was compared by the Kaplan-Meier log- rank test using SPSS program. Results: The female-to-male ratio was 1.5:1 (9 women and 6 men), and the mean age at diagnosis was 63.9 years (range, 44∼91). The mean tumor size was 6.3 cm (range, 4∼10 cm). Extrathyroidal invasion was present in 12 cases and distant metastasis at diagnosis was present in 6 cases. Surgery was performed in 8 cases. Radiotherapy was used for 10 cases and chemotherapy for 5 cases. The mean overall survival time of the 15 patients was 237 days (range, 28∼717 days). The 6∼, 12∼, 18∼ and 24∼ month survival rates were 33%, 26%, 13% and 0%. No association was found between survival and presenting symptoms, age, gender, tumor size, previous goiter history, extrathyroidal invasion, distant metastasis, surgery, radiotherapy or chemotherapy. A significantly better outcome was observed in patients received triple modality treatment (surgery, radiotherapy and chemotherapy) than in those received single or dual modality treatment (P=0.05). Conclusion: Although most patients with ATC had a poor prognosis, a multimodal approach including surgery, radiotherapy and chemotherapy, might improve survival. (Korean J Endocrine Surg 2005;5:75-80)
목차
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