Tc-99m Sestamibi Scintigraphy를 이용한 부갑상선과 갑상선 결절의 감별진단

• 영문명: Differentiation of Parathyroid and Thyroid Nodule by Tc-99m Sestamibi Scintigraphy
• 발행기관: 대한내분비외과학회
• 저자명: 서승원¹ 주재균¹ 윤정한¹ 제갈영종¹ 범희승² Seung Won Seo M.D.¹ Jae Kyun Joo M.D.¹ Jung Han Yoon M.D.¹ Young Jong Jaegal M.D.¹ and Hee Seung Bom M.D.²
• 간행물 정보: 『The Koreran journal of Endocrine Surgery』2권1호, 15~18쪽, 전체 4쪽
• 주제분류: 의약학 > 일반외과학
• 파일형태: PDF
• 발행일자: 2002.06.30

영문 초록

Purpose: Differentiation of parathyroid and thyroid nodule is often difficult even with aids of ultrasonography and computed tomography. Tc-9m sestamibi (MIBI) scintigraphy is useful in the detection of hyperfuntioning parathyroid nodules. However, its role in the differentiation between parathyroid and thyroid nodules including malignancies is not well studied. Therefore, the purpose of this study is to evlauate the role of Tc-99m MIBI imaing in the differentiation of parathyroid adenoma from thyroid malignancy. Methods: Six patients (4 women, 2 men, mean age 43 years) with parathyroid adenoma and 4 patients (2 women, 2 men, mean age 56 years) with thyroid papillary cancer were enrolled. Ten and 180 minutes after injection of 740 MBq Tc-99m MIBI, pinhole image of the anterior neck was obtained. Nodule-to-thyroid ratio (N：T) was measured from same sized region of interests over nodule and normal thyroid bed. Retention Index (RI) was calculated as N：T 10 minus N：T 180 divided by N：T 10. Results: Patients with parathyroid adenoma showed similar N：T 10 as those with thyroid cancer (1.09 ⁢/⁣ 0.35, 1.24⁢/⁣ 0.36, respectively, P＞0.05 ). However, RI of parathyroid patients was higher than thyroid cancer patients (0.64 ⁢/⁣ 0.29, ⁣0.12⁢/⁣ 0.20, respectively, P＜0.05). Conclusion: Parathyroid adenoma showed higher retention rate of Tc-99m MIBI than thyroid cancer. Therefore, differntiation of parathyroid and thyroid nodule could be possible using Tc-99m MIBI scintigraphy. (Korean J Endocrine Surg 2002;2:15-18)

키워드

Tc-99m sestamibi scintigraphy,Tc-99m MIBI, Parathyroid adenoma, Retention index