갑상선 분화암 수술 후 저용량 방사성 옥소(I-131)요법

• 영문명: Low-dose Radioactive I-131 Therapy Following Total Thyroidectomy for Differentiated Thyroid Cancer
• 발행기관: 대한내분비외과학회
• 저자명: 정성후 정연준 유희철 강남부 Sung Hoo Jung M.D. Yeon Jun Jeong M.D. Hee Chul Yu M.D. and Nam Poo Kang M.D.
• 간행물 정보: 『The Koreran journal of Endocrine Surgery』1권1호, 98~103쪽, 전체 6쪽
• 주제분류: 의약학 > 일반외과학
• 파일형태: PDF
• 발행일자: 2001.04.13

영문 초록

Purpose: To assess the effectiveness of low-dose (30 mCi) I-131 ablation therapy for remnant thyroid tissue following total thyroidectomy for differentiated thyroid cancer. Methods: Between March 1995 and December 1997, 48 patients were given ablative doses (30 mCi) of I-131 following total thyroidectomy for differentiated thyroid cancer in the presence of I-131 uptake in remnant thyroid tissue. The effective ablation of remnant thyroid tissue was determined using a subsequent I-131 whole body scan. If any remnant thyroid tissue remained, we repeated the same management protocol at 6-month intervals. Results: Thirty-eight (79.1%) patients displayed papillary, 8 (16.7%) follicular, 1 (2.1%) medullary and 1 (2.1%) Hurthle cell type cancer. Forty-eight patients underwent total thyroidectomy, 35 cases of which underwent central neck dissection, and 14 cases modified radical neck dissection. Postoperative complication developed in 8 cases, including 4 cases of transient hypoparathyroidism, 1 case of permanent hypoparathyroidism, 2 cases of transient recurrent laryngeal nerve palsy, and 1 case of wound hematoma. There was significant remnant thyroid tissue detected in 46 cases (95.8%) following total thyroidectomy, which were able to be ablated by low dose (30 mCi) I-131. There was no statistical difference between the operative procedures or the numbers of treatment of I-131. Conclusion: This data suggests that low-dose (30 mCi) I- 131 therapy is effective for the ablation of remnant thyroid tissue following total thyroidectomy for differentiated thyroid cancer. (Korean J Endocrine Surg 2001;1:98-103)

키워드

갑상선 분화암, 갑상선 전절제술, 저용량 옥소요법,Differentiated thyroid cancer, Total thyroidectomy, Low-dose I-131 therapy