갑상선 유두암 재발의 예측 인자로서 혈중 호중구-림프구 비율의 임상적 유용성

• 영문명: Clinical Significance of Blood Neutrophil-to-Lymphocyte Ratio in Patients with Papillary Thyroid Carcinoma
• 발행기관: 대한내분비외과학회
• 저자명: 한세웅 강상율 김선광 윤현조 정성후 Se Woong Han Sang Yull Kang Seon Kwang Kim Hyun Jo Youn Sung Hoo Jung
• 간행물 정보: 『The Koreran journal of Endocrine Surgery』14권4호, 184~189쪽, 전체 6쪽
• 주제분류: 의약학 > 일반외과학
• 파일형태: PDF
• 발행일자: 2014.12.30

영문 초록

Purpose: The neutrophil-to-lymphocyte ratio (NLR) is a strong predictor of poor prognosis in patients with various types of cancer. To date, the utility of NLR for prediction of prognosis in thyroid cancer patients has not been studied. Therefore, the aim of our study was to determine whether NLR is associated with other prognostic factors of papillary thyroid carcinoma and predictive of recurrence. Methods: We conducted a retrospective review of 367 patients who underwent thyroidectomy for papillary thyroid carcinoma from January 2005 to December 2007. We measured the white blood cell count including neutrophil and lymphocyte within one month preoperatively. The NLR was defined as the absolute neutrophil count divided by absolute lymphocyte count. Logistic regression analysis was applied for comparison of NLR with other prognostic factors, including tumor size, lymph node metastasis, multiplicity, extrathyroidal invasion, and TNM stage. We also determined the cut-off value of NLR with a prediction for recurrence. Results: Median age of patients was 47 years (16∼86 years) and the rate of papillary thyroid microcarcinoma was 65.7% (241/367 cases). Median follow-up period was 1,841 days (506∼3,135 days). The median value of NLR was 1.68 (0.66∼6.36). NLR was not related to any other prognostic factors of papillary thyroid carcinoma. The cut-off value of NLR for prediction of recurrence was 1.73, where the sensitivity was 66.7% and specificity was 69.8%. Conclusion: Patients with NLR equal to or higher than 1.73 showed significantly higher recurrence of papillary thyroid carcinoma. Further validation study should be conducted for clinical use of NLR as a prognostic marker.

키워드

호중구-림프구 비율, 갑상선암, 재발,Neutrophil-to-lymphocyte ratio, Thyroid carcinoma, Recurrence