중독성 갑상선 결절의 치료에 있어서 수술적 치료의 중요성

• 영문명: Significance of Surgical Treatment for Toxic Thyroid Nodule
• 발행기관: 대한내분비외과학회
• 저자명: 박귀숙 오은미 송원종 이영돈 정유승 Guisuk Park Eun Mee Oh Won Jong Song Young Don Lee Yoo Seung Chung
• 간행물 정보: 『The Koreran journal of Endocrine Surgery』13권3호, 151~156쪽, 전체 6쪽
• 주제분류: 의약학 > 일반외과학
• 파일형태: PDF
• 발행일자: 2013.09.30

영문 초록

Purpose: Autonomous hyperfunctioning thyroid nodules produce thyroid hormone independently of TSH. Of these, toxic thyroid nodules provoke hyperthyroidism and can be treated by surgery or radioactive iodine therapy. The aim of this study was evaluating the role of each treatment method in Korean patients with toxic thyroid nodule. Methods: From July 2008 to June 2013, 10 patients were diagnosed with toxic thyroid nodule. We diagnosed toxic thyroid nodule by thyroid function test and thyroid scan. Thyroid function test showed hyperthyroidism. Hot nodule and suppressed uptake surrounding thyroid tissue was observed on thyroid scan. We analyzed medical records of 10 patients retrospectively. Results: 9 patients were women and 1 patient was man. Median follow-up duration was 22 months. Most common symptom was neck mass (80%) and the median tumor size was 2.66 cm. 99mTc uptake increased by 6.41% on thyroid scan. All 10 patients refused radioactive iodine therapy and 3 of these denied even operation. In 7 patients underwent thyroidectomy, 4 patients were proved having thyroid malignancy (3 papillary thyroid carcinomas and 1 follicular thyroid carcinoma). Conclusion: In Korean patients, toxic thyroid nodule was likely to accompany thyroid malignancy and radioactive iodine therapy is contraindicated in this case. Therefore, we suggested that surgery has to be considered in the first place in treatment of toxic thyroid nodule.

키워드

자율기능성 갑상선결절, 중독성 갑상선 결절, 갑상선절제수술, 방사성요오드치료,Autonomous hyperfunctioning thyroid nodule, Toxic thyroid nodule, Thyroidectomy, Radioactive Iodine therapy