하시모토 갑상선염을 동반한 유두상 갑상선암의 임상병리학적 특징

• 영문명: Clinicopathologic Features of Papillary Thyroid Carcinoma Coexisting with Hashimoto's Thyroiditis
• 발행기관: 대한내분비외과학회
• 저자명: 강상현 하태권 박하경 이홍태 신재호 안민성 김광희 배기범 김태현 최창수 김진수¹ 김기훈¹ 김운원¹ 김상효 Sang Hyun Kang Tae Kwun Ha Ha Kyoung Park Hong Tae Lee Jae Ho Shin Min Sung Ahn Kwang Hee Kim Ki Beom Bae Tae Hyeon Kim Chang-Soo Choi Jin-Soo Kim¹ Ki-Hoon Kim¹ Woon-Won Kim¹ and Sang Hyo Kim
• 간행물 정보: 『The Koreran journal of Endocrine Surgery』13권1호, 8~13쪽, 전체 6쪽
• 주제분류: 의약학 > 일반외과학
• 파일형태: PDF
• 발행일자: 2013.03.30

영문 초록

Purpose: Hashimoto's thyroiditis (HT) is an important cause of hypothyroidism caused by autoimmune chronic lymphocytic thyroiditis. In order to attain a better understanding for use in treatment of papillary thyroid carcinoma (PTC) coexisting with HT, we conducted an analysis of the clinicopathologic features, as well as the importance of HT as a prognostic factor. Methods: In this retrospective study, we analyzed 341 patients who were histopathologically diagnosed with PTC following surgery. Results: PTC coexisting with HT was observed in 19.6% (67 patients) of all PTC patients. A statistically significant gender difference was observed in the group with HT (two male vs. 65 female), with a higher positive rate of anti-thyroglobulin antibody and smaller tumor size, compared to the PTC group without HT. When tumor size increased, a lower coexistence rate of HT was observed. No significant differences were observed in multifocality, cervical lymph node (LN) metastasis, coexistence of benign nodule, and extent of LN dissection. However, frequency of extrathyroidal extension was significantly lower and total thyroidectomy rate was higher in the group with HT. TNM stage and AMES stage were similar in both groups; frequency of high MACIS score showed a significant decrease in the group with HT. The recurrence rate and disease-free survival in patients with PTC were not significantly affected by coexistence of HT. Conclusion: We found a significant relationship with gender, extrathyroidal extension, and tumor size in PTC coexisting with HT. However, no significant differences in recurrence rate and disease-free survival were observed between groups. Therefore, coexistence in PTC could not be applicable as a prognostic factor of PTC.

키워드

유두상 갑상선암, 하시모토 갑상선염, 예후,Papillary thyroid carcinoma, Hashimoto's thyroiditis, Prognosis