갑상선 유두암에서 BRAFV600E 돌연변이와 연관된 임상병리학적 인자 및 초음파 소견과의 연관성

• 영문명: Association of BRAF^V600E Mutation with Poor Clinical Prognostic Factors and Ultrasonographic Findings in Cases of Papillary Thyroid Carcinoma
• 발행기관: 대한내분비외과학회
• 저자명: 최향숙 김광민 박준범 배금석 강성준 Hyang Suk Choi M.D. Kwang Min Kim M.D. Joon Beom Park M.D. Keum Seok Bae M.D. and Seong Joon Kang M.D.
• 간행물 정보: 『The Koreran journal of Endocrine Surgery』12권1호, 16~20쪽, 전체 5쪽
• 주제분류: 의약학 > 일반외과학
• 파일형태: PDF
• 발행일자: 2012.03.30

영문 초록

Purpose: This study evaluated the association of the BRAF^V600E mutation with known prognostic factors and ultrasonographic characteristics in cases of papillary thyroid carcinoma. Methods: Subjects included 169 patients who received thyroidectomy at Wonju Christian Hospital under the diagnosis of papillary thyroid cancer from February 2010 to October 2011. Results: Of the total patients who received thyroidectomy, there were 128 cases (75,7%) of BRAF^V600E mutation. Neither age nor sex were associated with the BRAF^V600E mutation. Tumor size, shape, margin, extrathyroidal extension, central node metastasis and lateral node metastasis were found not to be associated with the BRAF^V600E mutation. Tumor calcification, echogenicity and vascularity were also not associated with the mutation. Conclusion: As debate remains about the association between the BRAF^V600E mutation and clincopathologic factors and ultrasonographic characteristics in cases of papillary thyroid carcinoma, further study is needed. (Korean J Endocrine Surg 2012;12:16-20)

키워드

BRAF^V600E 돌연변이, 임상 병리학적 인자, 초음파 소견,BRAF^V600E mutation, Clinicopathologic factors, Ultrasonographic characteristics