녹차의 고포도당에 의한 신경세포 사멸 예방효과

• 영문명: Protective Effects of Green Tea Catechins against High Glucose-induced Cell Death in Neuron Cells
• 발행기관: 한국차학회
• 저자명: 박민정(Min Jung Park) 박수현(Soo-Hyun Park)
• 간행물 정보: 『한국차학회지』제18권 제3호, 62~67쪽, 전체 6쪽
• 주제분류: 농수해양 > 기타농수해양
• 파일형태: PDF
• 발행일자: 2012.09.30

영문 초록

Consumption of green tea (GT) is associated with decreased incidences of diverse diseases in humans. Epigallocatechin-3-gallate (EGCG) and EGC are major catechins of green tea. Hyperglycemia is thought to be a primary factor in the development of diabetic neuropathy. Neuronal cell loss is a general phenomenon of diabetic neuropathy. Therefore, we examined the preventive effects of green tea extracts (GTE), EGCG, and EGC against high glucose-induced death of PC12 neuronal, cells derived from the rat adrenal medulla. In present study, high glucose resulted in decreased cell viability and stimulated lipid peroxide [LPO] formation, and [3H]-glutamate uptake. Treatment with 10 mg/mL of GTE prevented high glucose-induced cell death, lipid peroxide formation, and [3H]-glutamate uptake in PC12 cells. In addition, treatment with EGCG and EGC prevented high glucose-induced cell death, LPO formation, and glutamate uptake. Thus, we found that green tea protected against hyperglycemia-induced cell death, and its main action was mediated through reduction of oxidative stress and glutamate uptake in neuron cells. In conclusion, GTE prevented high glucose-induced neuron cell death by decreasing oxidative stress and glutamate uptake in PC12 cells.

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green tea neuron apoptosis oxidative stress glutamate uptake