단일조사와 분할조사시 마우스 공장 소낭선세포의 방사선효과에 관한 실험적 연구

• 영문명: Radiation Effect on Mouse Jejunal Crypt Cells by Single and Split Irradiation
• 발행기관: 대한방사선종양학회
• 저자명: 高秉熙(Byung Hee Koh) 咸蒼谷(Chang Kok Hahm) 金禎鎭(Jung Jin Kim) 朴贊一(Chan Il Park)
• 간행물 정보: 『대한방사선종양학회지』제3권 제1호, 1~8쪽, 전체 8쪽
• 주제분류: 의약학 > 종양학
• 파일형태: PDF
• 발행일자: 1985.06.30

영문 초록

To determine the dose·survival and repair characteristics of the jejunal crypt cells, experimental study was carried out using total 70 mice. Single or split irradiations of 1,100 to 2,200 rad were delivered to whole bodies of C_57 BL mice, using a cesium 137 animal irradiator and those mice were sacrificed after 90 hours. The number of regenerating crypts per jejunal circumference was counted by a jejunal crypt cell assay technique and dose·response curve was measured. The results were as follows : 1. The average number of jejunal crypts per circumference in control group was 140. In a single irradiation group, the number of regenerated jejunal crypts was, 125, 56, 2 in each subgroup of 1,100 rad, 1,400 rad and 1,800 rad respectively. In split irraiation group, it was 105,44,2 in each subgroup of 1,400rad 1,800rad and 2,200rad respectively. 2. Mean lethal dose of mouse jejunal crypt cell was 167 and 169 rad respectively in a single and split irradiation. 3. Repair dose of sublethal damage was 280 rad. 4. Sublethal damage was completely repaired within 4 hours between the split dose of irradiation.