임상검체에서 Serratia spp.의 분리빈도와 항균제 감수성

• 영문명: Isolation Frequency and Antimicrobial Susceptibility of Serratia species from Clinical Specimens
• 발행기관: 고려대학교 보건과학연구소
• 저자명: 신현성(Hyun-Sung Shin) 박연보(Youn-Bo Park) 조경진(Kyung-Jin Cho)
• 간행물 정보: 『보건과학논집』保健科學論集 Vol.33 No.2, 19~32쪽, 전체 14쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2007.12.01

영문 초록

  Background : The most common hospital infections are of the urinary tract and respiratory diseases which covers three quarters of all the Serratia infections. That kind of nosocomial infections are from the urinary catheter or the instruments in the respiratory intensive care unit. Moreover the Serratia infection is closely related with the antibiotic resistance. The information on the antibiotic resistance against the Serratia spp. isolated from the patients admitted in the Korean medical institutions would be helpful to the building up a database for the antibiotic resistance of Serratia spp.
  Methods : A medical records on the total of 509 Serratia spp. isolated from 116,429 clinical specimens requested to the Depratment of Laboratory Medicine of “C” hospital during the period from Jan. 1, 2005 to Dec.. 31, 2006 were investigated retrospectively and analyzed. In the test for Serratia spp. isolation, the specimens were cultivated in the condition of 37℃ incubator for two or three days after inoculation in Nutrient agar and blood agar plate, then pure culture bacteria were isolated. The bacteria were analyzed by the VITEK Ⅱ. VITEK Ⅱ-GN cards and VITEK Ⅱ system AST-N041 cards respectively for identification and antimicrobial susceptibility patterns, and CLSI M7 A7-MIC was applied for performance standards for antimicrobial susceptibility testing.
  Results : The isolation frequencies of Serratia spp. were as follow, Serratia marcescens 94.7%, Serratia liquefaciens 4.1%, Serratia fonticola 0.4%, along with low frequencies in Serratia ficaria, Serratia odorifera, Serratia plymuthica and Serratia rubidaea. Seven strain Serratia spp. were identified with an isolation range of 0.2%-94.7%. The clinical materials showing over 5.0% isolation rate were 59.5% in sputum, 13.7% in urine, 5.7% in blood and 5.1% in wound against Serratia spp.. The antimicrobial agents that showed over 90.0% susceptibility were amikacin, cefepime, imipenenm, meropenem in Serratia marcescens, and piperacillin, tetracycline, amikacin, cefepime, cefotaxime, ceftazidime, gentamicin, ciprofloxacin, netilmicin, nitro furantoin, piperacillin+tazobactam, ofloxacin, ticarcillin, ticarcillin/clav.ac, and tobramycin in Serratia liquefaciens.
  Conclusion : Severn species of genus Serratia were isolated from the requested clinical materials. The antimicrobial agents showing over 90% susceptibility against the whole groups of Serratia spp.(S. marcescens +S. liquefaciens) were 100.0% in meopenem, 99.6% in imipenem, 95.1% in cefepime, and 95.0% in amikacin. Among the applied 22 antibiotics, four antibiotics showed ？90% susceptibility against S. marcescencs(18.2%), while fifteen showed ？75% susceptibility against S. liquefaciens.
  The increased number of resistant strains and ESBL producing Serratia spp. means that the number of available antimicrobial agents are becoming limited. Therefore, selecting effective antibiotics seems through the susceptibility test seems to be inevitable.

목차

Abstract
Ⅰ. 서론
Ⅱ. 재료 및 방법
Ⅲ. 결과
Ⅳ. 고찰
참고문헌

키워드

Frequency of Serratia species Antimicrobial susceptibility of Serratia spp. Serratia spp.