제2형 당뇨병 환자에서 인슐린저항성 지표와 프레밍험 위험도와의 관련성

• 영문명: The association between insulin resistance and Framingham risk score among type 2 diabetes
• 발행기관: 한국역학회
• 저자명: 박희숙(Hee Sook Park) 윤지은(Ji Eun Yun) 윤수진(Soo Jin Yoon) 조어린(Eurin Cho) 안경아(Kyung A Ahn) 박석원(Seok Won Park) 안철우(Chul Woo Ahn) 김대중(Dae Jung Kim) 송영득(Young Duk Song) 최영주(Young Ju Choi) 조미애(Mi Ae Cho) 이은직(Eun Jig Lee) 허갑범(Kap Bum Huh) 지선하(Sun Ha Jee)
• 간행물 정보: 『한국역학회지』韓國疫學會誌 第29卷 第1號, 46~58쪽, 전체 13쪽
• 주제분류: 의약학 > 면역학
• 파일형태: PDF
• 발행일자: 2007.06.30

영문 초록

  Background and purpose: Insulin resistance has been known to be associated with the risk of cardiovascular diseases. However, the relationship with Framingham risk score among type 2 diabetes has not been well known. We investigated the relationship between insulin resistance (IR) and the Framingham risk score(FRS) among type 2 diabetes in Korea.
  Methods: We estimated the 5-year risk of ischemic heart disease(IHD) based on Framingham equation among 1,941 diabetes patients(1,294 men and 647 women), who visited Huh"s clinic, enrolled from January 2003 to June 2006. IR, which was measured by insulin tolerance test (ITT), was divided into five groups(Q1 to Q5). High risk of IHD was defined as upper 10 percentile of FRS. Multivariate regression and logistic regression models were used to see independent association of higher quintiles of IR level, compared with lowest quintile(Q1) for the risk of IHD.
  Results: Mean (±standard deviation) 5-year FRS of study subjects were 8.40%(±6.89) for men and 5.92%(±5.23) for women. There were significant correlation between IR, body mass index, HbA1C, fasting glucose, triglyceride, LDL-cholesterol, C-peptide and FRS in both men and women. After adjusting for triglyceride, LDL-cholesterol, C-peptide, multivariate regression model analysis showed that IR was independently associated with the FRS. A positive association between IR and high risk of IHD was observed in men: highest versus lowest quintile of IR (odds ratio 5.45 in men and 4.71 in women).
  Conclusion: Increased IR level was independently associated with risk of IHD measured by FRS among type 2 diabetes in Korea.

목차

서론
연구대상 및 방법
연구결과
고찰 및 토의
연구 요약
참고문헌
Abstract

키워드

type 2 diabetes insulin resistance Framingham score ischemic heart disease