연골세포의 탈분화 및 세포고사 억제를 위한 기전연구

• 영문명: Regulation of Interleukin-1β-induced Dedifferentiation and Apoptosis via p38 Mitogen-activated Protein Kinase pathway in Articular Chondrocytes
• 발행기관: 고려대학교 보건과학연구소
• 저자명: 허정은(JeongEun Huh) 이찬진(ChanJin Lee) 김순기(SoonKee Kim) 김나래(NaRae Kim) 김현주(HyunJu Kim) 조경진(KyungJin Cho)
• 간행물 정보: 『보건과학논집』保健科學論集 Vol.31 No.2, 91~98쪽, 전체 8쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2005.12.01

영문 초록

  Interleukin-1 (IL-1)β in articular chondrocytes regulates differentiation, apoptosis, and inflammatory responses. It is still controversial, however, whether IL-1β induces chondrocytes dedifferentiation and death. We investigated the role of the mitogen-activated protein kinase (MAPK) subtypes on IL-1β-induced dedifferentiation and apoptosis, as indicated by the inhibition of type II collagen expression and proteoglycan synthesis of rabbit articular chondrocytes. IL-1β treatment did not affect activation of ERK-1/2, but stimulation of p38 kinase. Inhibition of phospho ERK-1/2 with PD98059 enhanced IL-1β-induced dedifferentiation, and apoptosis up to 13.5%, whereas inhibition of phospho p38 kinase with SB203580 inhibited dedifferentiation, and apoptosis. Our results indicate that SB203580, p38 kinase inhibitor, inhibits IL-1β-induced dedifferentiation, and apoptosis.

목차

Abstract
Ⅰ. 서론
Ⅱ. 실험방법
Ⅲ. 실험결과
Ⅳ. 토의 및 결론
참고문헌

키워드

Interleukin-1(IL-1)β chondrocytes dedifferentiation mitogenactivated protein kinase(MAPK) apoptosis