프레밍험 모형은 한국인의 허혈성심질환 발생률을 과대 추정한다

• 영문명: Framingham Equation Model Overestimates Risk of Ischemic Heart Disease in Korean Men and Women
• 발행기관: 한국역학회
• 저자명: 안경아(Kyung A Ahn) 윤지은(Ji Eun Yun) 조어린(Eo Rin Cho) 남정모(Chung Mo Nam) 장양수(Yangsu Jang) 지선하(Sun Ha Jee)
• 간행물 정보: 『한국역학회지』韓國疫學會誌 第28卷 第2號, 162~170쪽, 전체 9쪽
• 주제분류: 의약학 > 면역학
• 파일형태: PDF
• 발행일자: 2006.12.01

영문 초록

  Background: The prediction of the absolute risk of ischemic heart disease (IHD) is commonly based on the risk prediction equations, originated from the Framingham Heart Study.
  Method: Framingham equation model was applied to participants from 2001 Korean National Health and Nutrition Examination Survey (KNHNES) to estimate the 5 year risk of IHD among Koreans ranging from 30 to 74 year-olds. The estimated risks were compared to the incidence and admission rates from two statistical reports among Koreans. Five year admission rate was estimated by the annual report from National Health Insurance Corporation (NHIC).
  Results: The average ages (standard deviation) were 34.31(27.23) year-old for KNHNES and 48.26(12.87) year-old for Framingham population used in this study. The risk of IHD predicted by the Framingham equation model substantially exceeded the risks actually reported in Korea. Five-year predicted risks by Framingham equation model were 4.86% for men and 1.93% for women; whereas from incidence data in Korea, five-year risks for acute myocardial infarction (AMI) were for 0.47% for men and 0.18% for women. These AMI incidence was similar to the admission rate (0.34 for men and 0.15 for women) estimated by NHIC. Also, 5-year admission rate of IHD were 1.16 for men and 0.78 for women. The magnitude of risk overestimation by Framingham mode is approximately at least 150 to 320%.
  Conclusion: Korean guidelines for the management for high risk group of IHD need to develop and correct for overestimation to avoid inflation of costs in primary prevention.

목차

서론
연구대상 및 방법
결과
고찰
참고문헌
＝Abstract＝

키워드

Framingham model Ischemic heart disease risk Incidence Admission