운동과 2,3-DPG(diphosphoglycerate)와의 관계

• 영문명: Relative in Exercise and 2,3-DPG(diphosphoglycerate)
• 발행기관: 동아대학교 스포츠과학연구소
• 저자명: 강성훈(Kang Sung-Hwun) 양성우(Yang Sung-woo) 이재규(Lee Jae-Gue) 박일봉(Park Il-Bong) 차유림(Cha Yu-Rim) 오경식(Oh Kyung-Sik) 여남회(Yeo Nam-Hwoeh)
• 간행물 정보: 『스포츠과학연구논문집』제23집, 9~17쪽, 전체 9쪽
• 주제분류: 예술체육 > 체육
• 파일형태: PDF
• 발행일자: 2005.12.01

영문 초록

  2,3-DPG is synthesized from glycolytic intermediates by a pathway known as Rapoport-Luebering shunt. The production of 2,3-DPG depends on the relative amounts of its precursor, 1,3-DPG going into Rapoport-Leubering pathway and into the ATP-forming glycolytic pathway. Its concentration also depends on the rate of hydrolysis of 2,3-DPG The most important function of 2,3-DPG is its effect on the oxygen affinity of Hb. Normal Hb in deoxygenated state can bind 2,3-DPG in a molar ration of 1:1 which results in reduced oxygen affinity of Hb and enhanced oxygen delivery to tissues. In oxygenated state the ability of Hb to bind 2,3-DPG is decreased and most DPG is in free state. As the result the affinity of Hb to oxygen is increased and it binds more of oxygen. Changes in 2,3-DPG levels have important role in adaptation to hypoxia. In anemia and certain hypoximic conditions, 2,3-DPG level in erythrocytes increase and oxygen affinity of Hb is reduced resulting in improved delivery of oxygen to tissues. This study was invested relative in exercise and 2,3-DPG we had a conclusion as follows; 2,3-DPG was increased in anemia, congestive heart failure, heart disease, hyperthyroidism but it was decreased in diabetic. Hypoxia was decreased and extremely exercise was increased.

목차

Abstract
Ⅰ. 서론
Ⅱ. 본론
Ⅲ. 결론
참고문헌

키워드

2 3-diphosphoglycerate affinity hypoxia