임신중기 임산부의 산화스트레스와 영아의 출생 후 1년까지의 성장과의 연관성평가를 위한 예비조사

• 영문명: A Trial for Association between Oxidative Stress in Midterm Pregnancy and Postnatal Growth during the First Year of Life
• 발행기관: 한국역학회
• 저자명: 박혜숙(Byesook Park) 김영주(Young Ju Kun) 이화영(Hwa Young Lee) 박은애(Eun Ae Park) 장남수(Nam Soo Chang) 하은희(Eun Hee Ha) 박보현(Bo Hyun Park) 이보은(Bo Eun Lee) 홍주희(Ju Hee Hong)
• 간행물 정보: 『한국역학회지』한국역학회지 제26권 제1호, 17~26쪽, 전체 10쪽
• 주제분류: 의약학 > 면역학
• 파일형태: PDF
• 발행일자: 2004.06.01

영문 초록

Objectives: We aims to construct Infant Growth Cohort for evaluating whether oxidative stress in midterm pregnancy has an adverse effect on postnatal growth Methods and materials: From September 2001 to April 2004, we constructed an Ewha Infant Growth Cohort connected with the Ewha Pregnant Women Cohort We excluded mother-and-child pans in which the mother had experienced hypertension or diabetes during pregnancy and had multiple births for this study, which gave us 233 mother-and-child pairs for analysis We measured maternal serum homocysteine and urinary 8-hydroxyguanosine (8-OHdG) and malondialdehyde (MDA) at 24~28 weeks of pregnancy, and infant weights at birth and at 6 and 12 months postnatally We applied repeated-measures ANOVA with PROC MIXED to assess the significance of differences Results: We followed 64 and 85 infants at 6 and 12 months respectively The mean body weights were 3146 4 g at birth, 8229.7 g at 6 months, and 1006.47 g at 12 months The mean birth weight of Infants was lower in mothers with higher homocysteine levels (third and fourth quartiles), but body weights from the first-and fourth-quartile groups of maternal homocysteine levels lower than the others even though It was not statistically significant Body weights at birth and at 6 months in third- and fourth-quartile groups of 8-OHdG levels were lower than the others The body weights In the fourthquartile MDA group were significantly lower than the others at all time points. Conclusions: Maternal Oxidative stress In midterm pregnancy may cause postnatal growth retardation But, there were high late of follow up loss and various measurement errors Therefore, we need to have efforts for compete follow up and valid and reliable measurements.

목차

서론

연구대상 및 방법

연구결과

고찰

참고문헌

Abstract