외상 후 스트레스 장애 난민에 관한 뇌 영상 연구 동향: 주제범위 문헌고찰

• 영문명: Trends in Brain Imaging Research on Refugees with Post-Traumatic Stress Disorder: A Scoping Review
• 발행기관: 한국기초간호학회
• 저자명: 윤진수(Yun, Jin Soo) 김민수(Kim, Min Su) 추상희(Chu, Sang Hui)
• 간행물 정보: 『Journal of Korean Biological Nursing Science』제23권 제3호, 159~169쪽, 전체 11쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2021.08.31

영문 초록

Purpose: The purpose of this study was to analyze research trends and find whether Post-Traumatic Stress Disorder (PTSD) of refugees could affect structural or functional changes of brains of those under MRI, focusing on volumes, functional connectivities, and metabolites. Methods: A literature search was done using PubMed, Embase, RISS, and KMBase to identify studies that matched our research purpose. A total of eight studies were identified using Prisma flow diagram by two reviewers independently. Results: Eight studies were identified. Three studies were on North Korean defectors as subjects. The number of studies that observed structural changes, functional changes, and metabolite changes in brains was 2, 5, and 2, respectively. Although each study observed various parts of the brain, anterior cingulate cortex (ACC) was observed commonly in three studies. The PTSD group showed reduction of ACC volume and N-acetyl-aspartate (NAA) metabolite in ACC compared to the non- PTSD group. When exposed to negative stimuli, the PTSD group showed higher neural activity than the non-PTSD group, but not vice versa. Conclusion: ACC showed significant difference in volume, neural activity, and NAA metabolite between the PTSD and the non-PTSD group, resulting in significant differences in structural changes, functional changes, metabolite changes, respectively. This study showed the need for conducting more research using various biomarkers to clarify the relationship between PTSD of refugees and their brain changes.

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외상 후 스트레스 장애 자기공명영상 난민 Post-Traumatic Stress Disorders Magnetic Resonance Imaging Refugees