본문 바로가기

추천 검색어

실시간 인기 검색어

학술논문

Oral Pharmacokinetic Drug-drug Interactions between Amifampridine and Acetaminophen in Rats

이용수 9

영문명
Oral Pharmacokinetic Drug-drug Interactions between Amifampridine and Acetaminophen in Rats
발행기관
대한약학회
저자명
Jin-Woo Cheong Yeo-Dim Park Dang-Khoa Vo Han-Joo Maeng
간행물 정보
『약학회지』제68권 제2호(2024년), 98~104쪽, 전체 7쪽
주제분류
의약학 > 기타의약학
파일형태
PDF
발행일자
2024.03.30
4,000

구매일시로부터 72시간 이내에 다운로드 가능합니다.
이 학술논문 정보는 (주)교보문고와 각 발행기관 사이에 저작물 이용 계약이 체결된 것으로, 교보문고를 통해 제공되고 있습니다.

1:1 문의
논문 표지

국문 초록

영문 초록

Amifampridine, the first-line medication for Lambert-Eaton myasthenic syndrome (LEMS), is extensively metabolized by N-acetyltransferase 2 (NAT2). Drug-drug interactions (DDIs) can occur when co-administered with a NAT2 inhibitor and amifampridine. Acetaminophen is a widely used analgesic for mild to moderate pain, which is also known as a NAT2 inhibitor. In this work, we studied the effects of acetaminophen on the amifampridine pharmacokinetics in rats. Both acetaminophen (300 mg/kg) and amifampridine (2 mg/kg) were administered orally. In acetaminophen-treated rats, the systemic exposure to amifampridine significantly increased, and the ratio of the area under the plasma concentration-time curve for 3-N-acetylamifampridine to amifampridine (AUCm/AUCp) decreased markedly, which is likely due to the inhibition of NAT2 by acetaminophen. Also, the urinary amount excreted was increased in the acetaminophen-treated group, but the renal clearance remained unchanged. This oral pharmacokinetic drug-drug interaction study showed that orally administered acetaminophen significantly inhibits the NAT2-based metabolism of amifampridine and may cause meaningful DDIs.

목차

Introduction
Methods
Results
Discussion
Conclusion
Acknowledgment
Conflict of Interest
References

키워드

해당간행물 수록 논문

참고문헌

교보eBook 첫 방문을 환영 합니다!

신규가입 혜택 지급이 완료 되었습니다.

바로 사용 가능한 교보e캐시 1,000원 (유효기간 7일)
지금 바로 교보eBook의 다양한 콘텐츠를 이용해 보세요!

교보e캐시 1,000원
TOP
인용하기
APA

Jin-Woo Cheong,Yeo-Dim Park,Dang-Khoa Vo,Han-Joo Maeng. (2024).Oral Pharmacokinetic Drug-drug Interactions between Amifampridine and Acetaminophen in Rats. 약학회지, 68 (2), 98-104

MLA

Jin-Woo Cheong,Yeo-Dim Park,Dang-Khoa Vo,Han-Joo Maeng. "Oral Pharmacokinetic Drug-drug Interactions between Amifampridine and Acetaminophen in Rats." 약학회지, 68.2(2024): 98-104

결제완료
e캐시 원 결제 계속 하시겠습니까?
교보 e캐시 간편 결제