고양이 다낭성신장질환의 유전학적 연구 및 발병기전에 대한 고찰

• 영문명: A Review of the Genetic Studies and the Pathogenic Mechanism of Feline Polycystic Kidney Disease
• 발행기관: 한국동물보건학회
• 저자명: 이재연 백정인
• 간행물 정보: 『한국동물보건학회지』2권 1호, 1~10쪽, 전체 10쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2023.03.31

영문 초록

Autosomal-dominant polycystic kidney disease (ADPKD) is a progressive genetic disease in which multiple small and large fluid-filled sacs (cysts or cysts) are formed in one or both kidneys. Polycystic kidney disease in cats is classified as an autosomal dominant genetic disease and has been found to be caused by mutations in the PKD1 gene that is coding a unit of mechanosensitive calcium channel, polycystin 1. It shows that humans and cats share a genetic cause for polycystic kidney disease. In this paper, we try to understand the pathogenesis of polycystic kidney disease through the genetic mutations and protein functions of feline polycystic kidney syndrome reported so far, and discuss the direction of genetic research that needs to be performed in the future.

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키워드

Feline Mutation Polycystic kidney disease Polycystin