대체후보물질 탐색 알고리즘 개발을 위한 국내ㆍ외 기술동향 조사 연구

• 영문명: Review of Domestic and Foreign Technology Trends for the Development of Exploring Alternative Candidate Algorithms
• 발행기관: 한국환경보건학회
• 저자명: 최지원(Jiwon Choi) 박종서(Jongseo Park) 서명원(Myungwon Seo) 이영민(Young-Min Lee) 김선미(Sunmi Kim)
• 간행물 정보: 『1. 한국환경보건학회지』제49권 제1호, 11~21쪽, 전체 11쪽
• 주제분류: 공학 > 환경공학
• 파일형태: PDF
• 발행일자: 2023.02.28

영문 초록

Background: The need to develop alternative chemicals is increasing worldwide due to the strengthening of global chemical regulations and consumer safety awareness in the marketplace. Objectives: We aimed to review domestic and foreign technology trends for exploring alternative candidate algorithms that can be used to develop safer alternatives to strengthen global market competitiveness and protect public health in the future. Methods: We searched the current status of research trends, companies related to the development of alternative chemicals in domestic and foreign countries. For this, we referred to research papers and websites by companies and institutes related to such alternatives. Results: Among the domestic and foreign research trends, more studies in South Korea were focused on predicting molecular-based physicochemical properties and toxicity than were reporting on research exploring alternative candidates. Three web-based databases and six tools were being developed. More studies in other countries predicted information to consider in alternative development than reported on research exploring alternative candidates, and four web-based databases and three tools were being developed. Among the companies related to the development of alternative chemicals, 286 alternatives classified as ‘EVALUATED ALTERNATIVE’ in MARKETPLACE accounted for the most significant proportion in Europe on a continent basis, and the largest number in the United States (US) on a national basis. In South Korea, only significant companies were registered. Conclusions: In this study, it was found to be necessary to provide public technology support platforms to explore alternative candidates considering various aspects in order to support alternative development. In conclusion, exploring alternative candidate algorithms could contribute to the response to the global trends in the chemical industry and to supporting companies and researchers developing safer alternatives in the future.

키워드

Alternative candidates phase-out chemical alternative assessment in silico sustainable chemistry