폐경기 여성에서 나이관련황반변성과 여성 호르몬 요인과의 관계: 제5기 국민건강영양조사 자료

• 영문명: Female Hormone Factors Associated with Age-related Macular Degeneration in Menopausal Korean Women: KNHANES V
• 발행기관: 대한안과학회
• 저자명: 백승국(Seung Kook Baek) 이영훈(Young Hoon Lee)
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume58,number9, 1~8쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2017.09.30

영문 초록

Purpose: To investigate whether endogenous and exogenous female hormone exposures were associated with risks for age-related macular degeneration (AMD) in postmenopausal women. Methods: This study included 4,479 postmenopausal females aged 45 years and older who completed the Korea National Health and Nutrition Examination Survey (KNHANES) V. The participants were divided into 4 groups: subjects with AMD, subjects without AMD, subjects with early AMD, and subjects with late AMD. Variables associated with endogenous and exogenous female hormone exposures were analyzed. Results: Among the 4,479 participants, 516 were found to have AMD and 3,963 were normal. There was no significant difference between the AMD and normal groups execpt for age in the risk analysis. Of the total 516 AMD participants, 488 had early AMD and 28 had late AMD. Women with AMD who had used oral contraceptives longer in the past had significantly higher odds of late AMD than early AMD (odds ratio [OR] = 1.013, 95% confidence interval [CI]: 1.002-1.024). Increasing number of children was also associated with decreased odds of late AMD (OR = 0.672, 95% CI: 0.506-0.893). Conclusions: These findings suggest that exposure to endogenous and exogenous female hormones may influence the risk of AMD progression. J Korean Ophthalmol Soc 2017;58(9):1066-1073

키워드

Age-related macular degeneration Female hormones KNHANES V