비특이성안와염에서 고용량 부신피질호르몬 주사요법의 효과

• 영문명: Effect of Intravenous Methylprednisolone on Idiopathic Orbital Inflammation
• 발행기관: 대한안과학회
• 저자명: 정승아 윤진숙 이상열,Seung Ah Chung, MD, Jin SooK Yoon, MD, Sang Yeul Lee, MD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume51,number10, 1299~1304쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2010.10.15

영문 초록

Purpose: To evaluate the efficacy of intravenous methylprednisolone pulse therapy in patients with idiopathic orbital inflammation. Methods: Fifty-two patients who received three-day pulse methylprednisolone for acute severe swelling, loss of visual acuity, limitation of eye movement, diplopia, or pain were included in the present study. The lesions were divided into five subtypes using computed tomography or magnetic resonance imaging; anterior, lacrimal, myositic, diffuse and apical. A case diagnosed as sclerotic type was excluded. The response rate, recurrence rate and cure rate were assessed. Results: The total response rate to intravenous methylprednisolone from all groups was 84.6%, with 100% in the anterior subtype and 71.4% in the diffuse subtype. During the mean follow-up period of 10.5 months, 15.9% of patients experienced a recurrence after a mean of 5.7 months. Overall, the cure rate was 71.2%. Recurrence was more common in the younger patients, and three of the seven patients with recurrence had myositic inflammation. Conclusions: Intravenous methylprednisolone was effective in patients with severe idiopathic orbital inflammation. However, combining other treatment modalities in patients with diffuse or myositic subtypes and in younger patients who show relatively low response or high recurrence is recommended. J Korean Ophthalmol Soc 2010;51(10):1299-1304

키워드

Idiopathic orbital inflammation, Methylprednisolone, Pseudotumor, Steroid